TABLE 4.

Summary of all reported cases with autoantibody against IFN-γ in the literature^a

Sexb	Age (yr)	Ethnicity	NTMc	Site	Other infectious diseasesd	AAbe	Outcomef	Reference
M	47	Filipino	M. chelonae	Pericardium; skin; pleura; LN; bone marrow; liver	Pulmonary and LN Mycobacterium tuberculos is; CMV viremia; oral candidiasis	IgG	Died	5
F	25	Thai	M. chelonae	Bone marrow	B. cocovenenans disseminated infection	IgG4	Died	8
F	46	British	MAI	Bone; neck mass	None	IgG3	Healthy on long-term IFN-γ	10
M	32	South African	MAI	Spine	None	IgM	Improved after antibiotics	10
F	59	British	M. fortuitum	Lung	Pulmonary aspergillosis	IgM	Improved after antibiotics	10
F	44	Japanese	MAI	Bone and muscle abscesses	None	IgG	Improved after drainage; antibiotics and IVIg	11
F	35	Taiwanese	MAI	Bone; skin and soft tissue	Pneumonia	IgG	Complete resolution	14
F	40	Filipino	MAI; M. chelonae	LN; lung; skin	Meningoencephalitis	IgG	Persistent infection	14
F	39	Chinese-Vietnamese	Mycobacterium szulgai; M. kansasii; M. scrofulaceum	Bone; LN; lung; skin	M. tuberculosis	IgG	Persistent infection	14
F	34	Filipino	MAI; Mycobacterium abscessus; M. fortuitum	LN; lung	None	IgG	Persistent infection	14
F	30	Filipino	MAI	Appendix; bone; skin and soft tissue; pharyngeal space	VZV (multiple dermatomes)	IgG	Persistent infection	14
F	61	Filipino	M. abscessus; MAI	LN; lung	HCV; Pseudomonas aeruginosa bacteremia; Enterobacter cloacae pneumonia; Achromobacter xylosoxidans bacteremia	IgG	Persistent infection	14
M	54	Japanese	MAI	Lung; pleura; bone marrow; LN	Streptococcus pyogenes bacteremia/osteomyelitis	IgG	Improved after antibiotics	19

^aFive other cases of autoantibody against IFN-γ were reported without detailed information and therefore were not included in the table.

^bM, male; F, female.

^cNTM, nontuberculous mycobacteria.

^dCMV, cytomegalovirus; HCV, hepatitis C virus; VZV, varicella-zoster virus.

^eAAb, autoantibody.

^fIVIg, intravenous immunoglobulin.