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. 2010 Jun 2;17(7):1074–1078. doi: 10.1128/CVI.00103-10

FIG. 5.

FIG. 5.

IgG Anti-fHbp antibody responses (1/GMT) of mice immunized with WT or mutant fHbp adsorbed with aluminum hydroxide. In study 1, CD-1 mice were immunized with three doses of recombinant WT or mutant fHbp; in study 2, CD-1 mice were immunized with one dose of WT or mutant fHbp; in study 3, BALB/c mice were immunized with three doses of WT or mutant fHbp. Shaded bars, WT fHbp; open bars, E218A/E239A mutant fHbp. In study 1, the sera were pooled (3 pools per vaccine group, each pool from sera of 3 to 4 mice). In studies 2 and 3, individual sera were assayed (n = 6 to 8 mice per vaccine group). *, P = 0.02; **, P = 0.007. 95% CI, 95% confidence interval.