FIG. 2.

Nifurtimox resistance in vivo. Groups of 5 mice were infected with either WT or NfxR1 cells (1 × 10⁴ parasites). Twenty-four hours following infection, WT- and NfxR1-infected mice were either dosed with nifurtimox (100 mg kg⁻¹) via an intraperitoneal injection or left untreated. Data are presented in the form of a Kaplan-Meier survival plot. Animals that succumbed to drug toxicity rather than parasitemia are annotated (skull and crossbones). WT, pink; WT treated with nifurtimox, blue; NfxR1, green; NfxR1 treated with nifurtimox, red.