FIG. 4.

Blood exposure of fexinidazole and its metabolites. Levels of fexinidazole and two major metabolites (sulfone and sulfoxide) were monitored in blood samples collected from mice at defined intervals, following oral dosing of fexinidazole (200 mg kg⁻¹). The EC₉₉ values of fexinidazole and its sulfoxide and sulfone metabolites, established in vitro, are annotated as solid, dotted, and dashed lines, respectively. Symbols: closed squares, fexinidazole; open circles, sulfoxide; closed circles, sulfone. Data are the means of triplicate measurements.