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(A) Arithmetic mean darunavir (DRV) plasma concentrations at steady state after the administration of 900 mg darunavir with 100 mg ritonavir (RTV) once daily with or without 2 weeks of treatment with 600 mg efavirenz (EFV) once daily in healthy male and female subjects (inset, semilogarithmic scale). The EC50 of 55 ng/ml is indicated by the dashed line. (B) Individual darunavir 24-h trough concentrations before and after efavirenz treatment.
