TABLE 1.

Pharmacokinetics of darunavir when 900 mg was given once daily with ritonavir at 100 mg once daily, before and after administration of efavirenz at 600 mg once daily^a

Parameter	DRV-RTV		DRV-RTV + EFV		LS means		P value
	Mean	SD	Mean	SD	Ratio	90% CI
Cmin (ng/ml)	2,137	1,034	1,180	1,138	0.43	0.32-0.57	0.0003
Cmax (ng/ml)	10,967	3,320	10,027	2,552	0.92	0.82-1.03	0.23
Tmax (h)	4	2-6b	4	2-5b	NA		0.50
AUC (ng·h/ml)	103,261	32,963	89,498	33,889	0.86	0.75-0.97	0.049
t1/2 (h)	15.3	7.4	8.5	4.6	0.56	0.49-0.65	0.00001
CL/F (ml/h)	9,657	3,466	11,392	4,127	1.17	1.03-1.33	0.047

^aAbbreviations: RTV, ritonavir; DRV, darunavir; EFV, efavirenz; NA, not available; LS, least-squares; C_min, trough concentration in plasma; C_max, maximum concentration in plasma; T_max, time to the maximum concentration in plasma; AUC, area under the concentration-time curve; t_1/2, half-life; CL/F, clearance.

^bInstead of SDs, the values for the time to the maximum concentration in plasma are ranges.