TABLE 1.
Treatment of experimental endocarditis caused by MRSE-375 and GISE (NRS6) strains
| Strain and treatment group | No. of sterile vegetations/total no. (%) | Median (IQR) log10 CFU/g vegetation |
|---|---|---|
| MRSE-375 | ||
| Controla | 0/15 (0) | 7.4 (6-8.3) |
| SD-daptomycinb | 9/15 (60)c | 0 (0-4.1) |
| HD-daptomycind | 11/15 (73)e,f | 0 (0-1)e,g |
| SD-vancomycinh | 3/16 (19)c,e | 2 (2-2)e |
| HD-vancomycini | 5/15 (33)f | 2 (0-2.8)g |
| GISE (NRS6 strain) | ||
| Controla | 0/16 (0) | 8.4 (7.9-8.9)j |
| SD-daptomycinb | 1/17 (6) | 3.7 (2-6)c,k,l |
| HD-daptomycind | 0/16 (0) | 3.9 (2-5.8)c,k,l |
| SD-vancomycinh | 0/15 (0) | 7.1 (5.2-8.5)c,j,l |
a
The control animals were killed 48 h after the infection was started.
b
6 mg/kg/day i.v.
c
P = 0.02.
d
10 mg/kg/day i.v.
e
P = 0.002.
f
P = 0.03.
g
P = 0.01.
h
15 mg/kg i.v. every 12 h.
i
15 mg/kg i.v. every 6 h.
j
P = 0.06.
k
P = 0.09.
l
P = 0.02.