TABLE 3.
Hemofiltration settings and pharmacokinetic dataa
| Patient | Filter age (min) | Mean blood flow (liters/h) | Mean UFR (liters/h) | Urine vol (0-8 h) (liters) | AUC0-8 (mg·h/liters) | AUMC0-8 (mg·h2/liters) | MRT (h) | Extraction ratio | CLCVVHF (liters/h) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 30 | 12.7 | 4.7 | 0.06 | 109.1 | 13,762.5 | 126.1 | 0.71 | 3.9 |
| 2 | 15 | 18.0 | 6.0 | 0.03 | 126.0 | 18,542.6 | 147.2 | 0.80 | 4.0 |
| 3 | 80 | 17.4 | 4.6 | 0.00 | 155.5 | 25,563.3 | 164.4 | 0.77 | 3.5 |
| 4 | 5 | 16.9 | 3.8 | 0.00 | 130.6 | 27,856.1 | 213.4 | 0.71 | 3.4 |
| 5 | 5 | 13.8 | 3.8 | 0.00 | 292.3 | 79,766.3 | 272.9 | 0.75 | 2.7 |
| 6 | 7 | 16.8 | 4.4 | 0.19 | 128.5 | 30,265.1 | 235.6 | 0.71 | 3.0 |
| 7 | 10 | 14.4 | 3.9 | 0.00 | 218.3 | 38,325.4 | 175.6 | 0.74 | 3.4 |
| 8 | 25 | 17.4 | 4.6 | 0.14 | 112.8 | 18,303.7 | 162.2 | 0.70 | 3.8 |
| 9 | 5 | 21.0 | 4.0 | 0.09 | 118.7 | 18,439.9 | 155.3 | 0.81 | 4.1 |
| 10 | 60 | 16.8 | 4.5 | 0.06 | 175.8 | 28,025.3 | 159.4 | 0.73 | 3.5 |
| Median | 24 | 16.5 | 4.4 | 0.08 | 129.5 | 26,709.7 | 163.3 | 0.74 | 3.5 |
| 25th percentile | 5 | 15.0 | 3.9 | 0.04 | 120.5 | 18,465.6 | 156.4 | 0.71 | 3.4 |
| 75th percentile | 29 | 17.4 | 4.6 | 0.114 | 170.7 | 29,705.2 | 203.9 | 0.77 | 3.9 |
a
Abbreviations: UFR, ultrafiltrate flow rate; AUC0-8, area under the concentration-time curve during 8-hour dosing period; AUMC0-8, area under the moment curve during 8-hour dosing period; MRT, mean residence time; CLCVVHF, hemofiltration clearance.