FIG. 6.

Bacterial clearance and survival of WT and CR1⁺ transgenic mice infected with Streptococcus pneumoniae BG7322. (A) Blood clearance and/or growth of pneumococci in WT and CR1⁺ transgenic mice. WT mice and transgenic mice were infected i.v. with 2 × 10⁵ CFU of pneumococci. Bacteremia was determined at different time points. Data are presented as the mean CFU/ml of blood ± SEM for eight mice in each group. The asterisks indicate that bacteremia in deficient mice is significantly different (P < 0.001 by a Student's two-tailed t test). (B) Number of mice not yet moribund at each day following their infection as described above. It took a day longer for 50% of the CR1⁺ mice to become moribund compared to the C57BL/6 mice. This difference, however, was not statistically significant (P = 0.2 by two-tailed Mann-Whitney U test).