. 2010 Apr 19;78(7):3112–3117. doi: 10.1128/IAI.00078-10

TABLE 3.

Induction of AMPs in S. aureus-positive skin infection, stratified by severity

Clinical characteristic	HBD-3				HBD-2				RNase 7
Clinical characteristic	Ratio^a	95% CI	P value^b	P value^c	Ratio^a	95% CI	P value^b	P value^c	Ratio^a	95% CI	P value^b	P value^c
No. of recurrences
0-2	31.4	8.5-116.4	<0.001	0.012	220.9	19.6-2,487.5	<0.001	0.62	1.96	0.50-7.66	0.33	0.36
3-6	6.4	2.1-19.3	0.001		212.6	27.3-1,653.1	<0.001		0.70	0.22-2.20	0.54
>6	2.8	1.0-7.7	0.050		96.6	14.3-653.6	<0.001		1.31	0.26-2.23	0.63
Drainage
No	37.9	8.9-161.1	<0.001	0.011	196.4	15.6-2476.9	<0.001	0.87	1.69	0.45-6.33	0.44	0.42
Yes	4.3	1.8-10.2	0.001		152.9	33.3-701.5	<0.001		1.11	0.41-1.99	0.80

Ratio = 2^{−meanΔΔCT} for comparison of mRNA expression levels in 15 biopsy specimens of lesional skin versus 22 biopsy specimens of healthy skin (for number of recurrences) and in 14 biopsy specimens of lesional skin versus 21 biopsy specimens of healthy skin (drainage).

H₀, no induction in this group.

H₀, induction is the same in each group, tested against alternative hypothesis of a linear trend over groups (recurrences) or a difference between groups (drainage).