FIG. 5.

Number of bacteria in blood after infection. Samples of blood were taken from mice infected with strain H44/76 or the lpxL1 or lpxL2 mutant at 2 h (A) and 19 h (B) after administration. Serial dilutions of blood in PBS were plated to determine CFU. Results of one representative experiment of two independent experiments are shown. Data are expressed as means for three mice, and error bars indicate SEM. Asterisks indicate that the group that received an lpxL mutant was significantly different from the group that received the same dose of wild-type strain H44/76. *, P < 0.05; **, P < 0.01; ***, P < 0.001.