FIG. 5.

Infection of BALB/c, SCID, and T-cell-reconstituted SCID mice with 10³ genome copies of NMI. Mice were euthanized at 24 days p.i., spleen weights were recorded, and the bacterial burdens in both the spleens and lungs were determined. (A) Spleen weights expressed as a percentage of the mouse body weight at the time of euthanasia. ***, P < 0.001. recon., reconstituted. (B) NMI bacterial burdens in the spleen determined by quantitative RT-PCR. ***, P < 0.001. (C) NMI bacterial burdens in the lungs of BALB/c and T-cell-depleted BALB/c mice determined by quantitative RT-PCR. ***, P < 0.001. The data are representative of the results of one of at least two independent experiments performed with six mice per group.