TABLE 7.
Lineage | Weight (%) |
Fecal shedding (log CFU/g) |
||||
---|---|---|---|---|---|---|
Wild typea | ΔsigB mutantb | P valuec | Wild typed | ΔsigB mutante | P valuef | |
I | 101.1 ± 8.9 | 106.5 ± 5.6 | 0.2129 | 5.3 ± 0.9 | 3.1 ± 0.7 | 0.0163 |
II | 99.0 ± 8.4 | 106.6 ± 4.9 | 0.123 | 4.8 ± 1.5 | 0.0 ± 0.0 | 0.0163 |
IIIA | 99.4 ± 3.7 | 105.7 ± 3.3 | 0.0465 | 6.1 ± 1.4 | 2.6 ± 2.4 | 0.0472 |
IIIB | 91.6 ± 2.6 | 105.9 ± 9.2 | 0.0305 | 6.1 ± 0.1 | 3.3 ± 2.9 | 0.0532 |
Average weight (± standard deviation) of guinea pig infected with wild-type strain at 72 h postinoculation (after euthanasia), expressed as a percentage of the weight at zero time (inoculation), which was defined as 100%.
Average weight (± standard deviation) of guinea pig infected with the ΔsigB strain at 72 h postinoculation, expressed as a percentage of the weight at zero time, which was defined as 100%.
P value for t test for the weight of guinea pigs inoculated with the wild-type strain and the weight of guinea pigs inoculated with the ΔsigB strain. A P value of <0.05 indicates that there was a significant difference in the weight of animals at 72 h postinoculation.
Average fecal shedding (± standard deviation) of wild-type parent strain at 72 h postinoculation.
Average fecal shedding (± standard deviation) of ΔsigB strain at 72 h postinoculation.
P value for t test. A P value of <0.05 indicates that there is a significant difference in the average fecal shedding of L. monocytogenes between the wild-type and isogenic ΔsigB strains.