FIG. 2.

Secretory processes controlled by mammalian-like proteins in A. niger. The dashed arrows and text boxes indicate processes that are carried out by a majority of proteins more similar to human than to yeast proteins. 1, peptide biosynthesis and translocation to the ER; 2, addition of N-glycan; 3, glycoprotein folding; 4, N and O glycosylation; 5, N glycosylation after transport to Golgi equivalents (GEs); 6, protein sorting and formation of secretory vesicles; 7, vesicle fusion with the plasma membrane; EE, early endosomes; ERC, endosomal recycling compartment; OT, oligosaccharyltransferase complex; QC, quality control; X, proteins abundant after d-xylose induction.