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. 2010 May 24;30(14):3453–3459. doi: 10.1128/MCB.01459-09

FIG. 2.

FIG. 2.

Male hypersensitivity to oxidative stress is determined by the somatic sex determination pathway. (A) Schematic models of the C. elegans somatic sex determination signaling pathways. (B) X chromosome dosage is not involved in the male hypersensitivity. Both tra-1(e1099) XX males and tra-2(e1094) XX males show hypersensitivity to oxidative stress, similar to WT XO males. (C) tra-1 or tra-2 RNAi-treated hermaphrodites also show hypersensitivity to oxidative stress. (D) Survival of temperature-sensitive mutants of fem-1(hc17) and fem-2(b245) or WT males. Animals were scored for survival following exposure to NGM agar plates containing 3 mM sodium arsenite (B, C, and D). The mean ± SD for the fraction of live animals on each of four plates (50 animals per plate) is shown.