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. 2010 May 24;30(14):3453–3459. doi: 10.1128/MCB.01459-09

FIG. 3.

FIG. 3.

The MAB-3 gene, one of the TRA-1 target genes, plays a pivotal role in determining the male hypersensitivity to oxidative stress. (A) Effect of RNAi against TRA-1 target genes (fog-3, egl-1, or mab-3) on the male hypersensitivity to oxidative stress. (B) mab-3(e1240) males show strong resistance to oxidative stress, similar to WT hermaphrodites. (C) mab-23 is not involved in the male hypersensitivity. mab-23 RNAi or mab-3 RNAi was performed. (D) ref-1, one of the major MAB-3 targets, is not involved in the male hypersensitivity. ref-1 RNAi was performed with mab-3(e1240); him-8(e1489) males. (E) Effect of knockdown of all vit genes on the oxidative stress sensitivity of WT hermaphrodites. Animals were scored for survival following exposure to NGM agar plates containing 3 mM (A, B, and C) or 5 mM (D and E) sodium arsenite. The mean ± SD for the fraction of live animals on each of four plates (50 animals per plate) is shown.