TABLE 1.
Abundance of mRNA encoded by genes potentially downregulated by FIGLA
| Genea | Description | No. of peptides based on MS/MS | mRNA abundance inb: |
Null vs normal ovaries (fold change) | Null ovary vs normal testes (% change) | KO availablec | ||
|---|---|---|---|---|---|---|---|---|
| Normal ovary | Normal testis | Figla null ovary | ||||||
| 1700019M22Rik | RIKEN cDNA 1700019M22 | 3 | 0.0 | 19.8 ± 1.6 | 3.2 ± 1.2 | ∞ | 16 | |
| Ttll13 | Tubulin tyrosine ligase-like family member 13 | 2 | 1.8 ± 0.2 | 17.3 ± 8.3 | 59.1 ± 3.7 | 33.6 | 342 | |
| 1700009N14Rik | RIKEN cDNA 1700009N14 | 2 | 3.7 ± 0.7 | 27.1 ± 8.3 | 59.7 ± 6.7 | 16.2 | 220 | |
| Cyp17a1 | Cytochrome P450, family 17, subfamily a, polypeptide 1 | 10 | 2.3 ± 0.4 | 139.6 ± 7.0 | 29.1 ± 5.2 | 12.6 | 21 | 29 |
| Gsg1 | Germ cell-specific gene 1 | 10 | 4.7 ± 1.8 | 100.0 ± 0.4 | 52.2 ± 11.3 | 11.0 | 52 | |
| Tnp2 | Transition protein 2 | 4 | 8.5 ± 6.4 | 58.0 ± 6.0 | 92.8 ± 2.9 | 10.9 | 160 | 1 |
| Cypt4 | Cysteine-rich perinuclear theca 4 | 5 | 4.5 ± 0.1 | 28.3 ± 12.4 | 22.6 ± 3.7 | 5.0 | 80 | |
| Irgc1 | Immunity-related GTPase family, cinema 1 | 1 | 0.4 ± 0.1 | 24.2 ± 3.8 | 1.5 ± 0.9 | 4.3 | 6 | |
| Cypt3 | Cysteine-rich perinuclear theca 3 | 4 | 3.5 ± 1.8 | 61.5 ± 5.8 | 13.2 ± 8.8 | 3.7 | 21 | |
| Crisp2 | Cysteine-rich secretory protein 2 | 6 | 4.5 ± 2.0 | 308.7 ± 11.7 | 15.8 ± 7.2 | 3.5 | 5 | |
| Tdrd6 | Tudor domain-containing 6 | 3 | 0.5 ± 0.2 | 15.1 ± 4.1 | 1.9 ± 0.3 | 3.5 | 12 | 52 |
| Slc2a3 | Solute carrier family 2 (facilitated glucose transporter), member 3 | 2 | 9.9 ± 1.6 | 55.3 ± 2.0 | 30.8 ± 6.8 | 3.1 | 56 | 15 |
| 1700011E24Rik | RIKEN cDNA 1700011E24 | 2 | 1.3 ± 0.5 | 6.3 ± 0.6 | 4.0 ± 0.3 | 3.1 | 63 | |
| Adad1 | Adenosine deaminase domain-containing 1 (testis specific) | 3 | 24.9 ± 1.1 | 119.5 ± 16.9 | 66.1 ± 15.3 | 2.7 | 55 | 11 |
| Dkkl1 | Dickkopf-like 1 | 2 | 9.2 ± 5.8 | 30.4 ± 3.0 | 24.0 ± | 2.6 | 79 | |
| Spata19 | Spermatogenesis-associated 19 | 5 | 1.1 ± 0.0 | 32.4 ± 1.7 | 2.4 ± 0.3 | 2.2 | 7 | |
| Ly6k | Lymphocyte antigen 6 complex, locus K | 4 | 15.9 ± 0.3 | 11.4 ± 0.2 | 31.5 ± 0.3 | 2.0 | 276 | |
| Klhl10 | Kelch-like 10 (Drosophila) | 3 | 11.7 ± 0.1 | 33.2 ± 2.6 | 23.0 ± 1.1 | 2.0 | 69 | 54 |
| Lrrc27 | Leucine-rich repeat-containing 27 | 4 | 25.3 ± 8.3 | 125.6 ± 8.7 | 47.5 ± 0.5 | 1.9 | 38 | |
| 4930511I11Rik | RIKEN cDNA 4930511I11 | 3 | 2.2 ± 0.3 | 2.5 ± 0.7 | 3.3 ± 1.2 | 1.5 | 135 | |
a
Genes shown in boldface were downregulated in 7-week-old mouse TSPY1-Figla testes.
b
Compared to the Gapdh control, which was assigned a value of 1. Values are means ± SEM.
c
Reference in which a KO (knockout) homozygous null mouse line has been reported.