FIG. 7.
NBD-556-mediated enhancement of the neutralization activity of plasma IgG against the autologous isolate. (A) The sensitivities of the HIV-1Pt.3 primary isolate to the autologous plasma IgG (Pt.3-IgG) in the absence or presence of NBD-556 (1, 2, 4, and 8 μM) were determined by the MTT assay. (B) The sensitivities of the HIV-1Pt.3 primary isolate to KD-247 (anti-V3 MAb; diamonds) and 4E9C (anti-CD4i MAb; squares) in the absence (open symbols) or presence (filled symbols) of 5 μM NBD-556 were determined by the same assay. The data shown are representative of two or three separate experiments.