TABLE 2.
Combination indices for KD-247, 4C11, or 0.5δ and for sCD4 or NBD-556 against HIV-1JR-FL and HIV-1IIIB
| Combination | Virus | CI values at different ICsa |
||
|---|---|---|---|---|
| IC50 | IC75 | IC90 | ||
| KD-247+sCD4 | HIV-1JR-FL | 0.313 | 0.266 | 0.277 |
| KD-247+NBD-556 | HIV-1JR-FL | 0.174 | 0.043 | 0.011 |
| 4C11+NBD-556 | HIV-1IIIB | 0.473 | 0.445 | 0.860 |
| 0.5δ+NBD-556 | HIV-1IIIB | 47.8 | 20.1 | 8.56 |
a
The multiple-drug effect analysis of Chou et al. (6) was used to analyze the effects of the drugs in combination. IC, inhibitory concentration. CI < 0.9, synergy; CI = 0.9 to 1.1, additivity; CI > 1.1, antagonism. The data shown are representative of two or three separate experiments.