TABLE 1.
Parameters for compound crystals MK1 RT (3LP0), MK2 RT (3LP1), MK3 RT (3LP2), and MK3 RNase H (3LP3)
| Parameter | Compound crystal PDB IDa |
|||
|---|---|---|---|---|
| MK1 RT (3LP0) | MK2 RT (3LP1) | MK3 RT (3LP2) | MK3 RNase H (3LP3) | |
| Resolution (Å) | 50-2.80 | 50-2.23 | 50-2.80 | 50-2.80 |
| Completeness (%) | 91.8 (83.4) | 96.3 (97.2) | 97.1 (98.4) | 100 (100) |
| Avg redundancy (%) | 3.6 (2.5) | 5.1 (4.8) | 5.1 (5.1) | 5.8 (5.7) |
| Rsym (%) | 4.3 (43.0) | 4.9 (25.1) | 5.8 (39.0) | 9.8 (36.9) |
| <I/σI> | 23.4 (2.3) | 26.1 (4.9) | 27.0 (4.4) | 20.2 (6.7) |
| Space group | C2221 | C2221 | C2221 | P31 |
| a (Å) | 118.3 | 118.8 | 117.5 | 51.3 |
| b (Å) | 154.2 | 155.3 | 154.8 | 51.3 |
| c (Å) | 153.2 | 155.2 | 155.8 | 112.8 |
| α (°) | 90 | 90 | 90 | 90 |
| β (°) | 90 | 90 | 90 | 90 |
| γ (°) | 90 | 90 | 90 | 120 |
| RMS deviations | ||||
| Bond length (Å) | 0.007 | 0.006 | 0.007 | 0.006 |
| Bond angle (°) | 1.046 | 0.962 | 1.028 | 1.029 |
| No. of nonhydrogen atoms used in refinement | 7,918 | 8,035 | 7,914 | 2,104 |
| No. of water atoms | 52 | 175 | 62 | 18 |
| No. reflections total/no. reflections free set | 30,644/1,618 | 64,255/3,410 | 32,509/1,728 | 7,751/387 |
| Rwork/Rfree (%) | 24.8/31.0 | 26.8/29.2 | 24.9/29.6 | 22.9/28.8 |
a
Values in parentheses are for the highest-resolution bin.