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Model illustrating the consolidation of data obtained from macaques and mice infected with highly pathogenic 1918 and VN/1203 viruses. Provided is an illustration depicting our current understanding of influenza virus infections in macaques and mice. The network diagrams for macaques (8) and mice (Fig. 3B) emphasize the differential regulation of the inflammatory response and activation of inflammasome components that was found during 1918 and VN/1203 virus infections, respectively.
