FIG. 5.
Experiments to determine in vivo miRNA activity on alphavirus RNA replication. Groups of 16 mice were immunized with each VRP at 0 and 3 weeks. The mean number of HA-specific gamma interferon cytokine-secreting T cells/1 × 106 splenocytes 1 week after the prime (A) and 1 week after the boost (B) are represented. Error bar represents 1 standard error. The mean anti-HA specific ELISA titers 1 week after the prime (C) and 1 week after the boost (D) are represented. Error bar represents 1 standard error.