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. Author manuscript; available in PMC: 2010 Jul 6.
Published in final edited form as: Nat Genet. 2009 Aug 30;41(10):1127–1132. doi: 10.1038/ng.438

Figure 3. Mutant ERBB4 induces cell transformation and anchorage-independent growth in NIH 3T3 and SK-Mel-2 cells.

Figure 3

A. NIH 3T3 cells were transfected with the indicated constructs. The photographs show foci stained with Hema3 after 10 days. Ras G12V was included as a positive control for cell transformation. B. The graph indicates the average number of foci visualized in A. C. Transformation ability of melanoma SK-Mel-2 cells stably expressing either vector, WT ERBB4 or various ERBB4 missense mutants was assessed by foci formation in tissue culture flasks. The graph indicates the number of foci formed after 14 days.