Table 3.
Promoter methylation status of genes in ZR75-1 xenograft tumors
| Orthotopic | Subcutaneous | ||||||
|---|---|---|---|---|---|---|---|
| Gene | Symbol | %HM | %UM | %IM | %HM | %UM | %IM |
| ADAM metallopeptidase domain 2 | ADAM23 | 50.0 | 50.0 | 0.0 | 59.1 | 40.9 | 0.0 |
| Cyclin D2 | CCND2 | 83.6 | 16.4 | 0.0 | 91.2 | 8.8 | 0.0 |
| Cyclin-dependent kinase inhibitor 2A | CDKN1C | 23.0 | 77.0 | 0.0 | 16.2 | 83.8 | 0.0 |
| O-6-methlyguanine-DNA methyltransferase | MGMT | 75.9 | 24.1 | 0.0 | 89.6 | 10.4 | 0.0 |
| Stratifin | SFN | 15.3 | 84.7 | 0.0 | 4.6 | 95.4 | 0.0 |
HM = hypermethylated; UM = unmethylated, IM = intermediately methylation