Table 1.
Manufacturing information of oxacillin products included in the study (11 generics plus the innovator).
| OXACILLIN (OXA) PRODUCTS | BATCH | MANUFACTURER | DISTRIBUTOR | PERFORMED TESTS |
|---|---|---|---|---|
| OXA-BMS (innovator) | EL059 EG187 EF109 EF372 ED259 |
Bristol-Myers Squibb de Mexico. | Bristol-Myers Squibb | MA, MIC&MBC, NMTIM |
| OXA-BLA | A 4602 B 4603 |
Vitrofarma SA, Bogota, Colombia | Laboratorios Blaskov | MA, MIC&MBC, NMTIM |
| OXA-CAR | 309V1104 378V0705 |
Farmacologica SA, Bogota, Colombia | Carlon Ltda | MA, MIC&MBC, NMTIM |
| OXA-COL | 0010202 05103 |
Farmacologica SA, Bogota, Colombia | Colpharma Ltda | MA, MIC&MBC, NMTIM |
| OXA-EXP* | OX 010462 | Farmacologica SA Bogota, Colombia | Laboratorios Expopharma | MA, NMTIM |
| OXA-MEM | 110291 050239 090281 |
Vitrofarma SA, Bogota, Colombia | Memphis Products | MA, MIC&MBC, NMTIM |
| OXA-OPH | 080267 060249 |
Vitrofarma SA, Bogota, Colombia | Laboratorios Farmaceuticos Ophalac | MA, MIC&MBC, NMTIM |
| OXA-PEN* | 20275 30417 |
Farmacologica SA, Bogota, Colombia | Pentacoop SA | MA, MIC&MBC, NMTIM |
| OXA-QIM | 6400702 | Vitrofarma SA, Bogota, Colombia | Quimicol | MIC&MBC, NMTIM |
| OXA-SCA | OX-010462 | Farmacologica SA, Bogota, Colombia | Farmionni Scalpi S.A. | MA, NMTIM |
| OXA-SER | OX-010508 | Farmacologica SA Bogota, Colombia | Serpharma SA | MIC&MBC, NMTIM |
| OXA-VIT | 120198 090281 110291 |
Vitrofarma SA, Bogota, Colombia | Vitalis | MA, MIC&MBC, NMTIM |
Abbreviators: MA: microbiological assay; MIC&MBC: minimal inhibitory concentration and minimal bactericidal concentration; NMTIM: neutropenic mouse thigh infection model. *The data from one experiment involving these two generic products and the innovator had to be excluded from the analysis due to heavy contamination of agar plates containing thigh homogenates that prevented reliable colony counting