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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Curr Opin Infect Dis. 2009 Oct;22(5):471–476. doi: 10.1097/QCO.0b013e3283304eb6

Table 2. Recent specific genetic associations to different enteric infections in humans.

Pathogen Genetic associations
Norovirus HBGAs,
Clostridium difficile -251 in the IL-8 promoter gene.
Enterotoxigenic E. coli -1082, -819 and -592 in the IL-10 promoter gene.
Enteroaggregative E. coli -251 in the IL-8 promoter gene.
Vibrio cholerae HBGAs, rs17124508, rs11906665, rs1884884, rs17307318 and rs8115852 in the LPLUNC1 gene.
Salmonella spp HBGAs, Microsatellite IVS8CA in the CFTR intronic region, TNF gene polymorphisms, HLA-DRB1 *0301/6/8, *04 and *1001, HLA-DQB1 *0201-3 and *0401/2.
Inflammatory enteropathogens -4191 in the CD14 promoter gene, +1181 in the OPG gene, +632 lactoferrin exon 15 gene.
Entamoeba histolytica HLA-DQB1 *0601 and *1501.
Cryptosporidium spp HLA-DQB1 *0301, HLA-B*15.

HBGAs (Histo-blood group antigens), IL (Interleukin), LPLUNC1 (long palate, lung and nasal epithelium clone 1), CFTR (Cystic fibrosis transmembrane conductance regulator), TNF (Tumor necrosis factor), HLA (Human leukocyte antigen), CD14 (Cluster of differentiation 14), OPG (Osteoprotegerin).