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Summary of Dose-Limiting Toxicities
| Dose Level | |||||
|---|---|---|---|---|---|
| No. Entered |
No. Evaluable |
No. DLTs |
DLTs (# patients) |
||
| Oxaliplatin (mg/m2/dose) |
Irinotecan (mg/m2/dose) |
||||
| Diarrhea (3) | |||||
| Lipase (3) | |||||
| 60 | 20 | 3 | 3 | 3 | Amylase (2) |
| Colitis (1) | |||||
| Abdominal Pain (1) | |||||
| Headache (1) | |||||
| 40 | 15 | 7* | 6 | 1 | Diarrhea (1) |
| 60 | 15 | 3 | 3 | 2 | Diarrhea (1) |
| Hypokalemia (1) | |||||
One patient received an incorrect irinotecan dose of 20 mg/m2/d
