Table II.
Mean Blood Pressure (BP), Average Step 1 Dosage (mg/d), Mean Number of Drugs Prescribed, and BP Control Status at Year 3, by Randomized Treatment Group and Major Subgroup
| No. With Visit | Mean Blood Pressure (mm Hg) SBP/DBP | Average Step 1 Dosagea | Mean No. of Drugs | BP <140/90 mm Hg (%) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | A | L | C | A | L | C | A | L | C | A | L | C | A | L | |
| Male | 6165 | 3629 | 3599 | 134.2/77.3 | 135.3/76.5 | 135.6/77.2 | 19.1 | 7.5 | 27.8 | 1.7 | 1.7 | 1.9 | 65.4 | 63.7 | 61.9 |
| Female | 5097 | 3068 | 2824 | 135.8/77.2 | 136.3/76.4 | 138.2/77.6 | 18.4 | 7.0 | 27.6 | 1.6 | 1.6 | 1.8 | 61.8 | 62.1 | 55.3 |
| Black | 3755 | 2260 | 2123 | 136.2/79.0 | 137.8/78.5 | 140.2/79.9 | 18.8 | 7.7 | 29.8 | 1.6 | 1.7 | 2.0 | 59.4 | 56.0 | 51.0 |
| Nonblack | 7507 | 4437 | 4300 | 134.3/76.4 | 134.7/75.4 | 135.0/76.2 | 18.7 | 7.1 | 26.8 | 1.7 | 1.7 | 1.8 | 65.9 | 66.5 | 63.0 |
| Diabetic | 3955 | 2338 | 2210 | 136.0/76.3 | 137.3/75.7 | 138.5/76.4 | 19.1 | 7.5 | 27.8 | 1.7 | 1.8 | 1.9 | 61.3 | 59.5 | 56.6 |
| Nondiabetic | 7307 | 4359 | 4213 | 134.3/77.8 | 134.9/76.8 | 135.8/77.9 | 18.6 | 7.2 | 27.7 | 1.6 | 1.6 | 1.8 | 65.1 | 64.9 | 60.3 |
| Smoker | 2364 | 1450 | 1384 | 134.4/77.9 | 135.4/77.0 | 136.7/78.6 | 18.7 | 7.4 | 28.6 | 1.6 | 1.6 | 1.8 | 64.9 | 63.2 | 58.8 |
| Nonsmoker | 8898 | 5247 | 5039 | 135.1/77.1 | 135.8/76.3 | 136.8/77.1 | 18.8 | 7.2 | 27.5 | 1.7 | 1.7 | 1.8 | 63.5 | 62.9 | 59.1 |
| 55–64 years | 4876 | 2893 | 2809 | 134.0/79.0 | 134.9/78.3 | 135.7/79.4 | 18.8 | 7.5 | 27.7 | 1.7 | 1.7 | 1.8 | 65.1 | 64.8 | 61.2 |
| ≥65 years | 6386 | 3804 | 3614 | 135.6/75.9 | 136.3/75.0 | 137.5/75.9 | 18.7 | 7.1 | 27.7 | 1.7 | 1.7 | 1.8 | 62.8 | 61.6 | 57.3 |
| With ASCVD | 5266 | 3096 | 2982 | 134.4/76.3 | 135.2/75.7 | 135.9/76.4 | 18.6 | 7.1 | 27.1 | 1.7 | 1.7 | 1.8 | 64.7 | 64.6 | 60.0 |
| No ASCVD | 5996 | 3601 | 3441 | 135.3/78.1 | 136.2/77.1 | 137.5/78.3 | 18.8 | 7.4 | 28.3 | 1.6 | 1.6 | 1.8 | 62.9 | 61.6 | 58.1 |
| BMI ≥30 | 4709 | 2876 | 2646 | 135.4/78.0 | 136.4/77.4 | 137.1/78.0 | 19.0 | 7.5 | 28.4 | 1.7 | 1.8 | 1.9 | 61.5 | 61.1 | 57.6 |
| BMI <30 | 6553 | 3821 | 3777 | 134.6/76.7 | 135.2/75.8 | 136.4/77.0 | 18.6 | 7.2 | 27.2 | 1.6 | 1.6 | 1.8 | 65.4 | 64.4 | 60.0 |
| Antihypertensive medicationb | 10,211 | 6079 | 5800 | 135.0/77.3 | 135.8/76.4 | 136.8/77.5 | 18.9 | 7.3 | 28.1 | 1.7 | 1.7 | 1.9 | 63.6 | 62.8 | 58.8 |
| No antihypertensive medication | 1051 | 618 | 623 | 133.7/77.3 | 134.9/76.7 | 135.9/76.7 | 17.1 | 6.5 | 24.5 | 1.3 | 1.4 | 1.5 | 65.6 | 65.0 | 61.0 |
| eGFR <60 | 2700 | 1573 | 1509 | 135.8/76.6 | 136.2/76.0 | 136.5/76.4 | 19.2 | 7.3 | 27.9 | 1.7 | 1.7 | 1.9 | 63.2 | 60.8 | 58.4 |
| eGFR ≥60 | 8182 | 4883 | 4663 | 134.5/77.4 | 135.4/76.5 | 136.8/77.6 | 18.6 | 7.3 | 27.8 | 1.6 | 1.7 | 1.8 | 64.3 | 64.1 | 59.3 |
Abbreviations: A, amlodipine; ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index (kg/m2)= weight/(height)2; C, chlorthalidone; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate (mL/min/1.73m2); L, lisinopril; SBP, systolic blood pressure; SD, standard deviation. aIn mg/d. The percentages of participants on a step 1 drug are given in Table III. bAntihypertensive treatment before ALLHAT enrollment.