. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Brain Behav Immun. 2010 Mar 29;24(6):968–974. doi: 10.1016/j.bbi.2010.03.009

Table 3.

Changes in serum cytokines related to changes in symptom severity over eight weeks. of CXRT (estimate* (SE)).^†

	Five most severe symptoms^‡	All 15 symptoms	Esophagitis-related symptoms^‡	Affective symptoms^‡
Intercept	3.68 (3.34)	2.48 (2.51)	6.04 (2.87)^§	5.94 (3.07)
Days of radiation therapy	0.03 (0.01)^¶	0.02 (0.01)^∥	0.04 (0.01)^¶	0.005 (0.008)
sTNF-R1	1.51 (0.93)	1.74 (0.69)^§	1.15 (1.02)	1.87 (1.00)
IL-1RA	-0.86 (0.68)	-0.34 (0.51)	-1.40 (0.81)	-0.38 (0.77)
IL-6	0.32 (0.16)^§	0.09 (0.12)	0.77 (0.19)^¶	-0.06 (0.19)
IL-8	-0.15 (0.14)	-0.10(0.11)	-0.49 (0.17)^∥	-0.18 (0.16)
IL-10	0.65 (0.34)	0.42 (0.26)	0.43 (0.36)	-0.22 (0.36)
IL-12	0.19 (0.25)	0.01 (0.18)	0.17 (0.26)	0.02 (0.26)

CXRT: concurrent chemoradiation therapy; SE: standard error; sTNF-R1: soluble receptor 1 for tumor necrosis factor; IL: interleukin; RA: receptor antagonist.

^†

Age, sex, race, recurrence of cancer, dose of radiotherapy, BMI, previous chemotherapy, and type of radiotherapy were adjusted in all models.

^‡

The five most severe symptoms: pain, fatigue, lack of appetite, disturbed sleep, sore throat. Esophagitis-related symptoms: pain, sore throat. Affective symptoms: distress, sadness.

^§

p < .05.

^∥

p < .01.

^¶

p < .0001.