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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Biochem Pharmacol. 2010 Apr 22;80(5):762–770. doi: 10.1016/j.bcp.2010.04.020

Figure 1.

Figure 1

Diagrammatic representation depicting tumor and mesenchyme progressive stages during tumor development. With respect to the blood vessel and proximal tumor cells, distal cells reside in acidic and hypoxic conditions. The invasive tumor cells will travel through a stromal reaction that contains (among others) myofibroblastic stromal cells localized within the signature parallel-organized tumor-associated extracellular matrix, just prior to their intravasation towards hematogenous metastasis.