Table 1. Up and downregulated GO categories in T. cruzi-infected heart.

UPREGULATED
GOID	GO Name	Type	Measured	%Change	Z Score	PermuteP
1726	Ruffle	C	21	38.10	5.039	0
6955	immune response	P	108	19.44	4.817	0
8009	chemokine activity	F	19	36.84	4.592	0
5764	Lysosome	C	44	31.82	4.487	0
5783	endoplasmic reticulum	C	305	14.43	3.806	0
7242	Intracellular signaling cascade	P	169	12.43	3.302	0
6935	Chemotaxis	P	31	25.81	3.254	0.004
30036	actin cytoskeleton organization & biogenesis	P	32	12.50	3.232	0.002
4180	carboxypeptidase activity	F	11	27.27	3.22	0.007
16798	hydrolase activity, acting on glicosyl bonds	F	25	28.00	3.172	0.004
15629	actin cytoskeleton	C	40	10.00	3.09	0.007
5938	cell cortex	C	10	20.00	3.035	0.01
7015	actin filament organization	P	15	26.67	2.914	0.015
5279	amino acid-polyamine transporter activity	F	11	18.18	2.91	0.016
42552	Myelination	P	13	23.08	2.806	0.024
8285	negative regulation of cell proliferation	P	45	15.56	2.67	0.015
8284	positive regulation of cell proliferation	P	56	16.07	2.669	0.014
45596	negative regulation on cell differentiation	P	13	7.69	2.603	0.014
8283	cell proliferation	P	55	16.36	2.588	0.012
8201	heparin binding	F	28	21.43	2.585	0.019
6954	inflammatory response	P	67	11.94	2.582	0.008
9986	cell surface	C	43	18.60	2.347	0.026
6817	phosphate transport	P	40	17.50	2.18	0.039
4896	Hematopoietin/interferon class (D200 Domain) cytokine receptor activity	F	16	25.00	2.18	0.048
48754	branching morphogenesis of a tube	P	12	33.33	2.123	0.048
45165	cell fate commitment	P	16	12.50	2.113	0.038
42127	regulation of cell proliferation	P	17	0.00	2.055	0.045
7264	small GTPase mediated signal transduction	P	83	10.84	2.055	0.05

DOWNREGULATED
GOID	GO Name	Type	Measured	%Change	Z Score	PermuteP
5739	Mitochondrion	C	351	17.38	13.839	0
5737	Cytoplasm	C	613	2.61	5.628	0
3824	catalytic activity	F	104	5.77	5.241	0
16491	oxidoreductase activity	F	208	6.73	4.835	0
3954	NADH dehydrogenase activity	F	10	30.00	4.599	0.005
50660	FAD binding	F	34	17.65	4.541	0
30170	pyridoxal phosphate binding	F	31	16.13	3.871	0.002
5777	Peroxisome	C	51	13.73	3.839	0.002
6118	electron transport	P	189	7.41	3.727	0
9055	electron carrier activity	F	60	8.33	3.349	0.003
5975	carbohydrate metabolic process	p	81	6.17	3.169	0.001
16874	ligase activity	F	121	8.26	3.123	0.005
8483	transaminase activity	F	10	20.00	2.947	0.017
7169	transmembrane receptor protein tyrosine kinase signaling pathway	P	30	13.33	2.801	0.012
6631	fatty acid metabolic process	P	33	12.12	2.735	0.013
166	nucleotide binding	F	715	3.78	2.698	0.007
9058	Biosynthetic process	P	31	12.90	2.511	0.009
7050	cell cycle arrest	P	24	12.50	2.43	0.034
8152	metabolic process	P	288	8.68	2.319	0.025
6629	lipid metabolic process	P	87	8.05	2.041	0.043
16740	transferase activity	F	558	4.84	1.995	0.044

Note. C = cellular location, F = molecular function, P = biological process.