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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Brain Behav Immun. 2010 Mar 27;24(6):859–865. doi: 10.1016/j.bbi.2010.03.007

Figure 1.

Figure 1

After demyelination injury, CCR2 signaling was not activated in the spinal cord. A, MCP1::MCP1–mRFP1; CCR2::CCR2–EGFP mice were subjected to lysophosphatidylcholine (LPC)-induced focal demyelination of the sciatic nerve. There was no expression of MCP1 or CCR2 in the associated lumbar spinal cord level at detectable levels. Leukocytes outside the spinal cord were clearly visible (green arrow). B, CCR2 expression was also examined at the mRNA level by in situ hybridization. The spinal cord does not contain significant CCR2 expressing cellular components, whereas many cells in the sciatic nerve (C) express and DRG (D) express CCR2 receptors in the LPC group. DH, dorsal horn; DC, dorsal column. Scale bars 60μm. Courtesy of the Society for Neuroscience.