Table I.
- Potential Drugs for Aseptic Loosening.
| Drug Class | Drug | Approved Indication |
| Bisphosphonates | Alendronate, Risedronate, Zoledronate | Inhibition of osteoclastic activity |
| Anabolic Agents | PTH, Teriparatide, | Stimulation of osteoblastic activity |
| Dual agents | Strontium Ranelate | Inhibition of osteoclastic activity and stimulation of osteoblastic activity |
| NSAIDs | Celecoxib | Inhibition of COX2 and PG2 |
| TNF-antagonists | Etanercept, Infliximab, Adalimumab | Inhibition of osteoclastic activity |
| IL-1 Antagonists | Anakinra | Inhibition of osteoclastic activity |
| RANKL- Antagonists | Denosumab | Inhibition of osteoclastic activity |