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. 2010 May 2;2(5):285–297. doi: 10.18632/aging.100142

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Copyright: ©2010 A.Kondratova et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Circadian mutant mice do not demonstrate anxiety phenotype. (Upper panel, left) Average horizontal velocity for all genotypes measured during 1h on days 1 and 2. Average velocity does not significantly differ between wt and Bmal1-/- animals; slight (~15%) but statistically significant decrease in average velocity is detected for Clock/Clock and Cry1,2-/- mice compared with wt and Bmal1-/-. (Upper panel, right) Cumulative time spent in the center for all genotypes measured during 1 hr on days 1 and 2. (Lower panel) Time spent in the center square of the open field arena on days 1 and 2 by wt, Clock/Clock, Bmal1-/-, and Cry1,2-/- mice. *P<0.05.