Table 3.
Animals | Outcome |
---|---|
Male Fischer-344 rats Single oral dose of 10, 100, or 1000 mg/kg GaAs; analysis at 14 days [114]. |
Dose-dependent recovery of gallium (70–99%) and arsenic (56–91%) in the feces. Arsenic, but not gallium, detected in the blood. Significant increase in urinary uroporphyrin excretion with highest dose. No pathologic changes in lungs, liver, spleen, kidney, or testes. |
Male Wistar albino rats Single oral dose of 10, 200, or 500 mg/kg GaAs. Analysis at 1, 7, and 21 days [125]. |
Weight loss. Increased liver weight, increased serum gamma-glutamyltranspeptidase and serum aspartate aminotransferase activity, decreased hepatic malondialdhyde and glutathione content. Increased renal alkaline phosphatase activity. Decreased erythrocyte delta-aminolevulinic acid dehydratase (ALAD); increased urinary ALA and protein excretion. Dose-dependent decrease in spleen weight and cellularity, and decreased IgM production by antibody-forming cells in response to sheep erythrocytes. |