. 2010 May 10;7(5):2337–2361. doi: 10.3390/ijerph7052337

Table 3.

Toxicities of Orally Administered Gallium Arsenide in Animals.

Animals	Outcome
Male Fischer-344 rats Single oral dose of 10, 100, or 1000 mg/kg GaAs; analysis at 14 days [114].	Dose-dependent recovery of gallium (70–99%) and arsenic (56–91%) in the feces. Arsenic, but not gallium, detected in the blood. Significant increase in urinary uroporphyrin excretion with highest dose. No pathologic changes in lungs, liver, spleen, kidney, or testes.
Male Wistar albino rats Single oral dose of 10, 200, or 500 mg/kg GaAs. Analysis at 1, 7, and 21 days [125].	Weight loss. Increased liver weight, increased serum gamma-glutamyltranspeptidase and serum aspartate aminotransferase activity, decreased hepatic malondialdhyde and glutathione content. Increased renal alkaline phosphatase activity. Decreased erythrocyte delta-aminolevulinic acid dehydratase (ALAD); increased urinary ALA and protein excretion. Dose-dependent decrease in spleen weight and cellularity, and decreased IgM production by antibody-forming cells in response to sheep erythrocytes.

Animals

Outcome

Male Fischer-344 rats
Single oral dose of 10, 100, or 1000 mg/kg GaAs; analysis at 14 days [114].

Dose-dependent recovery of gallium (70–99%) and arsenic (56–91%) in the feces. Arsenic, but not gallium, detected in the blood. Significant increase in urinary uroporphyrin excretion with highest dose. No pathologic changes in lungs, liver, spleen, kidney, or testes.

Male Wistar albino rats
Single oral dose of 10, 200, or 500 mg/kg GaAs.
Analysis at 1, 7, and 21 days [125].

Weight loss. Increased liver weight, increased serum gamma-glutamyltranspeptidase and serum aspartate aminotransferase activity, decreased hepatic malondialdhyde and glutathione content.
Increased renal alkaline phosphatase activity. Decreased erythrocyte delta-aminolevulinic acid dehydratase (ALAD); increased urinary ALA and protein excretion. Dose-dependent decrease in spleen weight and cellularity, and decreased IgM production by antibody-forming cells in response to sheep erythrocytes.