Anti-depression behavior in the Porsolt forced swim task is greater among intact male and female adult rats compared to juvenile male and females rats. It is greater among proestrous or pregnant rats, compared to diestrous or post-partum rats. As well, it is greater among middle-aged reproductively competent rats compared to middle-aged rats that are reproductively senescent or transition to senescence. * indicates different from respective juvenile, diestrous, post-partum, or reproductively-senescent control, p < 0.05.