. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Psychoneuroendocrinology. 2009 Dec;34(Suppl 1):S143–S161. doi: 10.1016/j.psyneuen.2009.07.005

Table 2.

Provides the steroid sources and receptor targets of non-classical actions of neurosteroids

Receptor	Neurosteroid (Modulatory effect: + positive, - negative)
GABA_A	3α,5α-THP (+), THDOC (+), 3α-diol (+), pregnenolone sulfate (-), DHEA-S (-)
Glycine	P (-), 3α,5α-THP (-), pregnanolone (-), Pregnenolone sulfate (-) DHEA-S (-)
Sigma type 1	DHEA (+), DHEA-S (+), pregnenolone sulfate (+), P (-)
NMDA	DHEA (+), pregnenolone sulfate (+), E₂ (-)
AMPA	Pregnenolone sulfate (-)
Kainate	P (+), Pregnenolone sulfate (-)
Serotonin type 3	3α,5α-THP (-), P (-), E₂ (-), testosterone (-)
Neuronal nicotinic acetylcholine	3α,5α -THP (-), P (-), pregnenolone sulfate (-)