Table 1.
Mean (SD) systemic and portal pharmacokinetic parameters in Sprague–Dawley rats
|
Systemic |
Portal |
|||
|---|---|---|---|---|
| LDX | d-Amphetamine | LDX | d-Amphetamine | |
| Cmax (ng/mL) | 178.4 (153.1) | 124.5 (26.6) | 1759.5 (1075.3) | 336.8 (40.0) |
| Tmax (h) | 0.17 (0.0) | 1.7 (0.6) | 0.17 (0.0) | 1.0 (0.0) |
| AUClast (ng•h/mL) | 158.0 (89.4) | 511.5 (222.1) | 1501.1 (680.6) | 1301.5 (414.9) |
| AUCinf (ng•h/mL) | 115.5 (ND) | 528.0 (214.8) | 1507.0 (686.7) | 1315.8 (418.6) |
| t½ (h) | 0.9 (ND) | 2.5 (1.3) | 1.2 (0.4) | 4.4 (0.4) |
Abbreviations: LDX, lisdexamfetamine dimesylate; SD, standard deviation; Cmax, maximum plasma concentration; Tmax, time to maximum plasma concentration; AUClast, area under the plasma concentration-time curve from time 0 hour to last time point; AUCinf, area under the plasma concentration-time curve from time 0 hour to infinity; t 1/2, half-life.