Table 6.
Comparison of 124 PSC patients who had no varices at baseline with and without the presence of new varices
| Clinical features Median (IQR) or Number (%) |
Patients without varices (N=99) |
Patients with varices (N=25) |
P value* |
|---|---|---|---|
| Treatment with Ursodeoxycholic acid | 45 (45.5) | 18 (72.0) | 0.02* |
| Proportion of patients with advanced liver fibrosis at baseline |
30 (30.3) | 12 (48.0) | 0.09 |
| ALT at baseline (U/L) | 110 (73, 214) | 80 (55, 174) | 0.13 |
| AST/ALT ratio at baseline | 0.6 (0.5, 0.9) | 0.9 (0.6, 1.2) | 0.01* |
| ALP (U/L) | 431 (259, 710) | 576 (383, 774) | 0.16 |
| Total bilirubin (mg/dL) | 0.8 (0.6, 1.2) | 1.1 (0.7, 1.6) | 0.08 |
| Albumin at baseline (g/dL) | 4.1 (3.9, 4.3) | 3.9 (3.6, 4.2) | 0.05* |
| Total protein at baseline (g/dL) | 9.9 (9.2, 12.4) | 11.4 (9.5, 12.7) | 0.15 |
| Triglyceride at baseline (mg/dL) | 108 (76, 144.8) | 83 (70, 121) | 0.14 |
| HDL-cholesterol at baseline (mg/dL) | 62.5 (48.3, 75) | 70 (59, 77) | 0.08 |
| Hemoglobin at baseline (g/dL) | 14.0 (12.8, 14.9) | 13.2 (11.5, 14.3) | 0.05* |
| Platelet at baseline (X 109/l) | 263 (211, 327) | 225 (155, 283.5) | 0.02* |
| Mayo risk score at baseline | 0.13 (−0.43, 0.75) | 0.53 (−0.21, 1.29) | 0.10 |
| Albumin at the 2nd year (g/dL) | 4.2 (3.9, 4.4) | 3.8 (3.5, 4.1) | 0.0003* |
| Total bilirubin at the 2nd year (mg/dL) | 0.9 (0.6, 1.3) | 1.8 (1.0, 3.3) | 0.0003* |
| AST/ALT ratio at the 2nd year | 0.8 (0.6, 1.0) | 1.2 (0.8, 1.4) | 0.001* |
| AST at the 2nd year (U/L) | 47.5 (31, 84.3) | 63 (42.5, 102) | 0.06 |
| ALP at the 2nd year (U/L) | 252 (141, 377) | 274 (180, 574) | 0.16 |
| Triglyceride at the 2nd year (mg/dL) | 102 (68.3, 134) | 82.5 (51.5, 105.5) | 0.13 |
| Hemoglobin at the 2nd year (g/dL) | 14.0 (13.1, 15.3) | 13.2 (11.5, 14.4) | 0.01* |
| White cell count at the 2nd year | 6.5 (5.3, 8.4) | 4.8 (3.5, 6.9) | 0.003* |
| Platelet at the 2nd year (X 109/l) | 264 (212, 331) | 177 (98.5, 264) | 0.0003* |
| Rate of total bilirubin change per year (%) | 3.6 (−9.3, 25.0) | 16.7 (3.6, 70.0) | 0.003* |
| Rate of platelet count change per year (%) | −0.9 (−5.3, 6.6) | −5.6 (−16.9, −2.2) | 0.0003* |
| Duration from randomization to the first presence of varices (years) |
3.9 (3.0, 4.9) | 2.0 (1.9, 3.5) | 0.0004* |
Note:
*
P value < 0.05 and those variables with a P value < 0.2 by univariate analysis were included in Cox regression analysis.