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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: J Invest Dermatol. 2009 Aug 27;130(2):371–377. doi: 10.1038/jid.2009.252

Fig. 5. Attenuation of the inflammatory phenotype in K5.TGFβ1wt mice with Avandia@ treatment.

Fig. 5

(a) K5.TGFβ1wt mice with 8-weeks of Avandia@ treatment showed a significant reduction in skin inflammation as compared to non-treated transgenic mice. H&E staining shows reduced epidermal thickness with Avandia@ treatment. (b) The number of macrophages stained by BM8 was significantly decreased in the skin of K5.TGFβ1wt mice treated with Avandia@ for 8 weeks. (c) mRNA expression levels of inflammatory cytokines and chemokines were all significantly reduced (n=5, p<0.01) in the skin of K5.TGFβ1wt mice treated with Avandia@ for 8-weeks, in comparison with non-treated K5.TGFβ1wt skins. The bar in panel (a) and (b) represents 40μm.