Table 1. Inhibition of Plk1 PBD by Compounds 1−4.
compound | PBD inhibitory activitya | Kd (μM) |
---|---|---|
1 | high | 0.445 |
2 | moderate | 2.7 (estimated) |
3 | no activity | |
4 | not determined |
Measured by an ELISA-based Plk1 PBD competition assay.
compound | PBD inhibitory activitya | Kd (μM) |
---|---|---|
1 | high | 0.445 |
2 | moderate | 2.7 (estimated) |
3 | no activity | |
4 | not determined |
Measured by an ELISA-based Plk1 PBD competition assay.