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IRF-3 attenuates reovirus virulence. Two-day-old IRF-3+/+ and IRF-3−/− mice were inoculated with 107 PFU of T1L p.o. (A), 104 PFU of T3SA+ p.o. (B), or 104 PFU of T1L i.c. (C). Mice (n = 25 to 39) were monitored for survival for 21 days. *, P < 0.001 as determined by log-rank test in comparison to IRF-3+/+ mice; d, days.
