FIG. 4.

Relevant sequence regions from clonal, near-full-length gag amplified from plasma (pl) or from either resting (HLA-DR⁻) or activated (HLA-DR⁺) CD4⁺ T cells. The date of sample acquisition and number of clones that are identical to the displayed sequences are noted. The HLA-B*27-restricted epitope KK10 (Gag 263-272) and HLA-B*57-restricted epitopes IW9 (Gag 147-155), KF11 (Gag 162-172), TW10 (Gag 240-249), and QW9 (Gag 308-316) all are denoted in shaded boxes. Sites of compensatory mutations for KK10 (S173) (42) and TW10 (H219, I223, M228) escape mutants also are shaded, and for ES7 the DL15 epitope is displayed. Sequences from 2004 and 2005 for ES3, ES7, ES8, and ES9 have been previously reported and are shown for comparative purposes only.