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Gp41 (DSL) mutants are resistant to PF-68742 but not to T20 or MAb b12. Viral entry assays in TZM-bl target cells were performed in the presence of PF-68742 (A), b12 (B), and T20 (C) against the LAI-JRFL molecular clone and a variety of corresponding mutants in the DSL region of gp41. Experiments were performed in triplicate. LAI-JRFL contains the Env ectodomain of HIV-1JR-FL in a HIV-1LAI backbone. Sequences of the gp41 (DSL) mutants are shown in Table 1.
