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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: J Med Chem. 2008 Sep 24;51(20):6460–6470. doi: 10.1021/jm800692a

Figure 3.

Figure 3

Inhibition of dCTP incorporation by α,β-m-dCTP (13). DNA synthesis was assayed on a single-nucleotide gapped DNA substrate where the templating nucleotide in the gap was dG. In this assay, the concentration of dCTP was 20 μM. Dixon analysis for competitive inhibition indicates that the Ki for 13 is 0.9 μM (solid line).