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. 2010 May 3;285(27):20818–20826. doi: 10.1074/jbc.M110.128835

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Immunofluorescence microscopy of Lmna^+/+, Lmna^LAO/LAO, and Lmna^PLAO/PLAO fibroblasts with an antibody against lamin A/C (red) and a rat monoclonal antibody against prelamin A (green). These images reveal a higher frequency of misshapen nuclei in Lmna^LAO/LAO fibroblasts. Cells were grown in the presence of vehicle (DMSO) alone (panel A), or with an FTI (ABT-100, 2 μm) (panel B). Treatment of cells with an FTI results in an accumulation of prelamin A in Lmna^+/+ and Lmna^PLAO/PLAO fibroblasts, but not in Lmna^LAO/LAO fibroblasts.