FIGURE 1.

Sequence alignment of TMEM59 and its homolog TMEM59L. Alignment of the protein sequences of human TMEM59 (323 amino acids) and its human homolog TMEM59L (342 amino acids, 32% identity between TMEM59 and TMEM59L). Both proteins are type I transmembrane proteins. The signal peptide is underlined, the transmembrane domain is marked by a box, the putative N-glycosylation site is marked with an asterisk, and the antibody epitopes are underlined (dashed). Identical amino acids are on a dark background, similar amino acids are on a light gray background. Between humans and mice, the amino acid sequence of TMEM59 is highly conserved (93.8% identity, 97.2% similarity to mouse). Apart from the transmembrane domain, no other known functional domains are found in TMEM59. TMEM59 is mostly found in vertebrates, but orthologs are also found in some insects (28.5% identity, 44% similarity to Ixodes scapularis), but not in other invertebrates, such as Caenorhabditis elegans or Drosophila melanogaster.