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. 2010 Apr 28;285(27):20664–20674. doi: 10.1074/jbc.M109.055608

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Control proteins do not affect APP shedding and maturation. A, control plasmid (con), HA-TMEM59 or HA-TMEM59-KKXX were transfected into HEK293 cells. The lysate (lys) was blotted against cellular APP (22C11), TMEM59 (HA.11), and GFP as a transfection control, the supernatant (sup) was blotted against secreted APPsα (W02). The vertical black lines in the gels indicate that the samples were run on the same gel, but not directly next to each other. B, control plasmid (con), HA-TMEM59, or golgiVENUS were transfected into HEK293 cells. The experiment was carried out as described in A, golgiVENUS was detected by anti-GFP.