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. 2010 May 3;285(27):20982–20992. doi: 10.1074/jbc.M109.092031

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Lysosomes are the substrates for tubulogenesis. A, electron-dense organelles in γA3-GFP and hcRed-LC3ΔG-cotransfected cells resemble lysosomes (right panel, arrow) versus organelles from γA3-GFP-tranfected cells in which the tubules (left panel, arrow) retained electron-dense properties whereas lysosomal-like organelles were less electron-dense. B, colocalization of γA3-GFP with lysosomal marker LAMP-2 indicates Pcdh-γs target to lysosomes, implicating them as the substrate for tubule growth. C, NH₄Cl inhibition of lysosomal acidification reduces tubulogenesis. Enlarged vacuoles (arrow) only occasionally sprouted tubules (arrowhead). N, nucleus; M, mitochondria.