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. 2010 May 3;285(27):21175–21184. doi: 10.1074/jbc.M110.112482

FIGURE 7.

FIGURE 7.

Klf4 regulated Gata4 expression by binding to the Gata4 promoter region. A, a schematic diagram of the Gata4 promoter is shown. A consensus Klf4 binding site, 5′-(G/A)(G/A)GG(C/T)G(C/T)-3′, is located within the Gata4 promoter, which contains 4 GC-rich elements and an E box. Numbers represent bp. B, association of Klf4 with the promoter regions of the Gata4 gene and the c-fos gene was determined by in vivo ChIP assays in the heart of SM22α-CreKI−/Klf4loxP/loxP and SM22α-CreKI+/Klf4loxP/loxP mice at P14 (n = 3). *, p < 0.05 compared with control mice. Ab, antibody.